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Enzymatic decomposition of a locked nucleoside phosphoramidate monitored by 31P NMR spectroscopy
 Procházková, Eliška ; Hřebabecký, Hubert ; Nencka, Radim ; Dračínský, Martin
Phosphoramidate derivatives are often used as prodrugs of modified nucleosides. The crucial step for the biologically active compound release in cells is then enzymatic hydrolysis of the phosphoramidate derivative. The enzymatic decomposition of a nucleoside prodrug 1 was monitored using 31P NMR spectroscopy and the structure of the reaction products was determined by 1D and 2D (COSY, HSQC, HMBC) NMR experiments and compared with the products obtained with non-enzymatic hydrolysis of the prodrug.
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